Occlusal adjustment is thought to have the potential to cause serious harm (e.g., somatoform selleckchem disorder by occlusal adjustment; the experience that panelists treated), because the current clinical guidelines panelists who are TMD specialists have encountered quite a few cases of somatoform disorder after occlusal adjustment. The cost of occlusal adjustment by Japan’s national healthcare service is presumed to be the lowest level in the world. In fact, the clinical guidelines committee recommends that occlusal adjustment should not be performed, for the following reasons. The effects

of occlusal adjustment are uncertain and the potential harm is serious. Occlusal adjustment is an irreversible procedure ON 1910 and may cause serious symptoms. The quality of evidence for occlusal adjustment is extremely low. Occlusal adjustment is negatively recommended. At the panel conference for the clinical guidelines, several medical consumers made comments critical of occlusal adjustment treatments. They

complained that occlusal adjustments were performed at the first visits without careful consideration and caused serious symptoms. They also did not receive full consultations with informed consent. Some thought that occlusal adjustment for natural teeth should be banned. The medical consumers’ significant concerns about occlusal adjustment indicate that further research is needed regarding patient education, diagnosis, and treatment methods for occlusal adjustment. For TMD symptoms, we recommend against occlusal adjustment about primary treatment

(Grade 1D). The current clinical guidelines Molecular motor for occlusal adjustment are as follows: 1. In the occlusal adjustment methods by original theory, healthcare providers should perform occlusal adjustments only after providing complete information to the patient about the benefits and risks of this treatment and obtaining the patient’s written informed consent. High-quality evidence (i.e., research articles) about TMD treatment is limited, as originally expected during the creation of the clinical guidelines for stabilization splint therapy. However, the existence of multiple randomized clinical trials for TMD is commendable. One of the limitations is that discrepancies of the outcome measures among studies make comparisons of the outcomes difficult. The current guidelines committee advocates that unification of the outcome measures and clinical assessments and the formulation of evaluative standards would contribute to the development of future TMD research. In addition, the diagnostic criteria for temporomandibular disorders (DC/TMD) have come under review. The unification and formulation are expected to be beneficial for the treatment of TMD. The articles on mouth-opening exercise were all written by Japanese researchers.