We speculate that gefitinib has a potential autologous
immunological anti-tumor activity.”
“Background: Colorectal cancer remains one of the leading causes of death in the world. Surgery still remains the mainstay of treatment for primary and metastatic colorectal cancer. Immunotherapy used as an adjunct to surgery can play an important role in controlling the spread of tumour.
Methods: The online databases PubMed, Medline, Scirus U0126 and Medscape Oncology were used to identify articles of relevance. Keywords included; “”Immunotherapy”", “”Cellular Immunotherapy”", “”Metastatic Colorectal Cancer”", “”Monoclonal Antibody”" “”Tumour Vaccines”" and “”Adoptive Cell Therapy”". The databases search was from the period of June 1995 until May 2010
inclusive.
Results: Our understanding of tumour immunology has allowed see more the development of some successful therapies. Immunotherapy through the use of monoclonal antibodies is an effective adjunct to chemotherapy for metastatic colorectal cancer. Other modalities that are in the stages of development are cellular and conjugated vaccines. However, these vaccines are being experimented in advanced stages of colorectal tumours.
Conclusion: Colorectal cancer vaccines are being developed for advanced stages of colorectal tumour. However, their use as an early adjunct could potentially limit the spread of tumour or even result in cure. Further trials are required to ensure the safety and efficacy of cellular vaccines against colorectal tumours to allow their use on patients early in their disease presentation. (C) 2010 Elsevier Ltd. All rights reserved.”
“We present in this paper a direct comparison of the optical properties of InP- and GaAs-based quantum cascade laser waveguides operating in the midinfrared wavelength range. The absorption loss and optical confinement were calculated using a two-dimensional electromagnetic finite-element method. The effect on the waveguide properties of SiO2, Si3N4, As2S3, and Ge0.25Se0.75 used as electrical AS1842856 insulation layers is investigated. The results indicate that a careful
choice of this particular layer according to the geometrical structure and the emission wavelength should enhance the laser performance.”
“The docetaxel and cyclophosphamide (TC) regimen is increasingly popular as adjuvant chemotherapy for operable breast cancers. We conducted a retrospective study in Hong Kong to evaluate the toxicity of this regimen in Chinese patients.
Between January 2007 and May 2008 76 female Chinese patients with resected stage I-III operated invasive breast cancer were treated with 4 cycles of TC (75 and 600 mg/m(2), respectively, administered i.v. every 3 weeks for four cycles) in two public regional cancer centers of Hong Kong. A total of 24 (32%) patients also received primary prophylactic ciprofloxacin (500 mg twice daily, day 5-14). Chemotherapy-related toxicities were graded by the CTCAE version 3.0.