Upon entering the abdomen, a large amount of blood was encountered and immediate control of the abdominal aorta was obtained to manage the ongoing hemorrhage and facilitate resuscitation which ultimately required 12 units of pRBCs, 4 units of fresh frozen plasma (FFP) and 6 units of platelets. A Selleck CYC202 bleeding source was identified in the left upper quadrant (LUQ) in the retroperitoneal fat which was oversewn. The abdomen was packed with laparotomy pads and closed; the blood loss was estimated to be 8000 cc. Figure 1 CT scan of the abdomen with left adrenal mass (white arrow) and associated intra-peritoneal

hemorrhage (black arrow) obtained on presentation to the outside hospital. The patient was subsequently transferred to our facility for further care. On arrival he was intubated LB-100 and sedated with a blood pressure of 90/35 mmHg, heart rate 129 bpm, Hct 36.3%, INR 2.7 and fibrinogen 117 mg/dL. Alisertib molecular weight On initial examination his abdomen was tense and distended, and his extremities were cold. Ongoing hemorrhage was suspected given the coagulopathy and persistent hypotension, therefore aggressive resuscitation with blood products was resumed. An initial bladder pressure of 33 mmHg along with poor urine output,

hypotension and a tense abdominal examination raised suspicion for an evolving abdominal compartment syndrome; therefore a second emergent exploration was undertaken. On entry into the abdominal cavity, the right colon was found to be frankly ischemic

and persistent hemorrhage from the LUQ was again noted. As the source of bleeding could not be readily identified, an emergent splenectomy was performed, and laparotomy pads were again packed into the LUQ. Once adequate control of the bleeding was obtained with packing, attention was turned to performing a right hemicolectomy. A Bogota bag with a wound V.A.C (KCI, TX) was then fashioned for temporary abdominal closure. Following closure of the abdomen, the patient suffered cardiac arrest with pulseless electrical activity. Advanced cardiac life support measures were initiated and a perfusing rhythm was obtained shortly thereafter. Given the history of Cobimetinib cost MEN2A and bilateral adrenal masses, the diagnosis of occult pheochromocytoma was entertained. The blood pressure swings were controlled with phentolamine and a sodium nitroprusside infusion with good effect. The patient was returned to the surgical intensive care unit for further management. In the intensive care unit, the patient continued to have a labile blood pressure, a persistent base deficit, decreasing hematocrit and drainage of large amount of blood from the VAC, therefore he was emergently taken to interventional radiology. Diagnostic angiography revealed contrast extravasation from the left adrenal artery which was embolized with 250 micron Embozene™ (CeloNova BioSciences, GA) microspheres and Gelfoam™ (Pfizer, NY) slurry to good effect (Figure 2).