The shelf seas cover only about 8% of the global ocean area but have over 20% of the global marine primary production (Pauly and Christensen, 1995) due to high nutrient input from terrestrial runoff and atmospheric deposition. It is an interface linking energy, heat, water and matter fluxes between land, ocean and atmosphere. All this together creates a highly dynamic environment, often biologically very active, that is now suffering from an increasing number of anthropogenic stressors such Nutlin-3a cell line as habitat loss, overharvesting, pollution from

toxins and nutrients, de-oxygenation, invasion of new species and, more recently, ocean acidification and climate-change. Protection of the coastal ocean and the services it provides is high on the political agenda, and policies and strategies are formulated for sustainable

management from an ecosystem perspective to ensure future maintenance of this Cell Cycle inhibitor resource for human welfare. Global climate model results indicate that significant environmental changes can be a reality before the end of the 21st century (e.g. IPCC, 2007 and IPCC, 2013). This includes changes in temperature, global and regional atmospheric circulation patterns, ice conditions and the hydrological cycle (e.g. Christensen et al., 2007 and Meehl et al., 2007). Obviously climate change will affect environmental objectives and the implementation of the different policy instruments. The Marine Strategy Framework Directive (MSFD) includes descriptors for eutrophication and marine food chains. The first descriptor (D1), concerning biodiversity, states that “distribution and abundance of species are in line with prevailing Rho physiographic, geographic and climatic conditions”, indicating that a changing climate in fact could revise certain environmental indicators. Recent studies indicate that the prospects for fulfilling obligations specified within the OSPAR and HELCOM conventions may become significantly more difficult given natural responses to climate change ( OSPAR, 2009 and HELCOM, 2013a and references therein). Several among the national environmental objectives may also be affected

by climate induced stressors. For example in Sweden, in addition to the most obviously affected objective – “Reduced Climate Impact” – there are possible impacts concerning at least “A Balanced Marine Environment”, “Flourishing Coastal Areas and Archipelagos”, “Zero Eutrophication”, “A Non-Toxic Environment“, “Natural Acidification Only” and “A Rich Diversity of Plant and Animal Life” ( Swedish Environmental Protection Agency, 2012). Linked to these objectives is the ability to provide ecosystem services such as biodiversity, biochemical regulating services, food provisioning and even cultural services ( Garpe, 2008). During the BONUS+ – science for a better future of the Baltic Sea region 2009–2012 research program (www.bonusportal.