Epidermal cysts, when intact, show arborizing telangiectasia; conversely, ruptured epidermal cysts reveal peripheral, linear, branched vessels (45). According to reference (5), dermoscopic characteristics of both steatocystoma multiplex and milia frequently consist of a peripheral brown ring, linear blood vessels, and a uniform yellow background encompassing the entire lesion. Notably, the linear vessels that define other cystic lesions discussed earlier are not representative of pilonidal cysts, which exhibit a different pattern involving dotted, glomerular, and hairpin-shaped vessels. Among the differential diagnoses for pink nodular lesions are pilonidal cyst disease, amelanotic melanoma, basal cell carcinoma, squamous cell carcinoma, pyogenic granuloma, lymphoma, and pseudolymphoma (3). In our cases and two existing case reports, common dermoscopic signs of pilonidal cyst disease appear to include a pink background, central ulceration, a peripheral distribution of dotted vessels, and the presence of white lines. Dermoscopic examination reveals central, structureless, yellowish areas, alongside peripheral hairpin and glomerular vessels, as characteristic features of pilonidal cyst disease, as our observations suggest. To summarize, the dermoscopic characteristics described previously effectively distinguish pilonidal cysts from other skin growths, and dermoscopy can bolster the diagnosis in patients where a pilonidal cyst is suspected clinically. Subsequent studies are essential for a more precise depiction of the common dermoscopic features and their prevalence in this condition.

Dear Editor, in the English medical literature, the uncommon condition of segmental Darier disease (DD) has been reported in about 40 instances. The disease's causation is hypothesized to involve a post-zygotic somatic mutation within the calcium ATPase pump, which appears only in lesional skin. Patients with segmental DD, specifically type 1, showcase lesions that follow Blaschko's lines on one side of the body; type 2, conversely, displays focal areas of heightened severity within the context of generalized DD (1). The difficulty in diagnosing type 1 segmental DD arises from the frequent absence of a positive family history, the disease's delayed appearance usually during the third or fourth decade, and the absence of characteristic features linked to DD. Within the differential diagnosis of type 1 segmental DD, acquired papular dermatoses, exemplified by lichen planus, psoriasis, lichen striatus, or linear porokeratosis, are characterized by a linear or zosteriform arrangement (2). In this report, we present two cases of segmental DD, the first being a 43-year-old female who had suffered from pruritic skin alterations for five years, with symptoms worsening during specific seasons. Examination of the left abdomen and inframammary area demonstrated small, keratotic papules, a light brownish to reddish hue, arranged in a swirling configuration (Figure 1a). A dermoscopic examination revealed yellowish-brown, polygonal or roundish areas, demarcated by a surrounding, whitish, featureless zone (Figure 1b). read more Dermoscopic brownish polygonal or round areas are histopathologically associated with hyperkeratosis, parakeratosis, and dyskeratotic keratinocytes, a finding confirmed by the biopsy specimen (Figure 1, c). The 0.1% tretinoin gel prescription resulted in a significant improvement for the patient, a finding supported by Figure 1, part d. The second case study concerned a 62-year-old woman who presented with a zosteriform pattern of small red-brown papules, eroded lesions, and yellow crusts on the right side of her upper abdomen, as illustrated in Figure 2a. In the dermoscopic image (Figure 2b), polygonal, roundish, yellowish areas were observed, encircled by a structureless field characterized by whitish and reddish coloring. The histopathological analysis indicated prominent compact orthokeratosis interspersed with small parakeratosis foci, a granular layer containing dyskeratotic keratinocytes, and the presence of suprabasal acantholytic areas, strongly suggesting the diagnosis of DD (Figure 2, d, d). Topical steroid cream and 0.1% adapalene cream were prescribed to the patient, resulting in an improvement. A final diagnosis of type 1 segmental DD was reached in both cases due to the corroboration of clinical and histopathological findings; the histopathology report alone failed to differentiate acantholytic dyskeratotic epidermal nevus, which is clinically and histologically indistinguishable from segmental DD. Supporting the diagnosis of segmental DD was the late emergence of symptoms and their worsening due to external factors, for instance, heat, sunlight, and sweat. While clinical and histopathological observations typically confirm the type 1 segmental DD diagnosis, dermoscopy proves indispensable in the diagnostic process by reducing alternative diagnoses, while paying attention to their characteristic dermoscopic patterns.

Condyloma acuminatum, while not commonly found in the urethra, typically manifests in the distal part when it does affect the urethra. Various treatment options for urethral condylomas have been reported in the literature. These treatments, characterized by their comprehensiveness and variability, include laser treatment, electrosurgery, cryotherapy, and the topical application of cytotoxic agents, such as 80% trichloroacetic acid, 5-fluorouracil cream (5-FU), podophyllin, podophyllotoxin, and imiquimod. Intraurethral condylomata treatment continues to favor laser therapy. In a case study of a 25-year-old male patient with meatal intraurethral warts, 5-FU treatment was effective, overcoming previous failures with laser therapy, electrosurgery, cryotherapy, imiquimod, and 80% trichloroacetic acid applications.

The group of skin disorders known as ichthyoses is characterized by erythroderma and a generalized scaling pattern. The nature of the connection between ichthyosis and melanoma remains poorly understood. Here, we present a singular case of acral melanoma, specifically located on the palm of an elderly patient, complicated by congenital ichthyosis vulgaris. The biopsy findings indicated a melanoma with ulceration, exhibiting a pattern of superficial spread. As far as we know, no acral melanomas have been observed in the population of patients with congenital ichthyosis. Even though ichthyosis vulgaris is present, the potential for melanoma to spread and metastasize justifies the necessity of regular clinical and dermatoscopic examinations in these patients.

This case report concerns a 55-year-old male patient with a diagnosis of penile squamous cell carcinoma (SCC). community geneticsheterozygosity In the patient's penis, a mass was identified, its size expanding gradually over time. We surgically excised the mass by performing a partial penectomy. Through histopathological analysis, a highly differentiated squamous cell carcinoma was ascertained. A polymerase chain reaction test detected the genetic material of human papillomavirus (HPV). HPV type 58 was detected in the squamous cell carcinoma through sequencing analysis.

Multiple genetic syndromes exhibit a pattern of cutaneous and extracutaneous abnormalities, a widely reported phenomenon. Even though many syndromic combinations have been described, some still elude classification. parasitic co-infection The Dermatology Department received a patient with multiple basal cell carcinomas, the source of which was a nevus sebaceous, a case report we present here. The patient's medical history indicated cutaneous malignancies, along with palmoplantar keratoderma, prurigo nodularis, hypothyroidism, multiple lumbar abnormalities, a uterine myoma, an ovarian cyst, and a highly atypical colon adenoma. The co-occurrence of multiple conditions could potentially point to a genetic source for the diseases.

Drug-induced vasculitis is a consequence of drug exposure and the subsequent inflammation of small blood vessels, which can cause damage to the affected tissue. Reports in the medical literature have documented rare cases of drug-induced vasculitis stemming from the use of chemotherapy or concurrent chemoradiotherapy. Small cell lung cancer (SCLC), stage IIIA (cT4N1M0), was the conclusion of our patient's assessment. After four weeks from the commencement of the second cycle of carboplatin and etoposide (CE) chemotherapy, the patient developed a rash and cutaneous vasculitis concentrated on the lower limbs. CE chemotherapy was ceased, and symptomatic relief was provided through methylprednisolone administration. With the prescribed corticosteroid treatment, there was a positive change in the local indicators. Completion of chemo-radiotherapy signaled the commencement of four cycles of consolidation chemotherapy incorporating cisplatin, bringing the total number of chemotherapy cycles to six. Clinical examination corroborated the continued regression of the cutaneous vasculitis. Elective radiotherapy to the brain was implemented subsequent to the completion of consolidation chemotherapy. The patient was kept under clinical watch until the disease's return. The platinum-resistant disease prompted subsequent chemotherapy administrations. Sadly, the patient's life ended seventeen months after receiving an SCLC diagnosis. Based on our current review, this constitutes the first documented case of lower extremity vasculitis observed in a patient receiving concomitant radiotherapy and CE chemotherapy as part of the initial treatment protocol for SCLC.

Traditionally, (meth)acrylates-induced allergic contact dermatitis (ACD) afflicts dentists, printers, and fiberglass workers in the occupational setting. The deployment of artificial nails has been associated with documented instances of problems affecting both nail technicians and clients who utilize them. (Meth)acrylates in artificial nails are a significant factor in ACD, raising concerns among both nail technicians and consumers. The case details a 34-year-old woman who developed severe hand dermatitis, predominantly on her fingertips, and frequent facial dermatitis, after two years of employment in a nail art salon. The patient's artificial nails, in use for the past four months, were a result of her nails' tendency to split, which required regular gel treatment for protection. At work, she suffered a series of asthmatic episodes. Patch tests were conducted for baseline series, acrylate series, and the patient's own material.