Surgical treatment includes simple closure of the perforation, GSK2126458 mouse ileal resection, and side-to-side ileo-transverse colostomy or diverting ileostomy [148, 152, 153]. Primary INK128 repair should be performed for patients with minor symptoms and with perioperative findings of minimal fecal contamination of the peritoneal cavity. In the event of enteric perforation, early repair is typically more effective than a temporary ileostomy

given that repair is more cost effective and is free of ileostomy-related complications. However, in delayed cases, there can be severe inflammation and edema of the bowel, resulting in friable tissue that complicates handling and suturing of the bowel. Primary closure of the perforation is therefore likely to leak, which is the etiological basis of the high incidence of fecal peritonitis and fecal fistulae associated with the procedure. Surgeons should perform a protective ileostomy to address fecal peritonitis and reduce mortality rates in the immediate term. The ileostomy serves to divert, decompress, and exteriorize, and in

doing so, appears to have lower overall morbidity and mortality rates than other surgical procedures. The ileostomy is particularly useful for patients in critical condition presenting late in the course of illness when it often proves to be a life saving procedure. Acute cholecystitis A laparoscopic cholecystectomy is a safe and effective treatment for acute cholecystitis. (Recommendation 1A). The laparoscopic versus open cholecystectomy debate has been extensively investigated. Beginning OSI-906 nmr in the early 1990s, techniques for laparoscopic treatment of the acutely inflamed gallbladder were streamlined and today the laparoscopic cholecystectomy is employed worldwide to treat acute cholecystitis. Many prospective trials have demonstrated

that the laparoscopic cholecystectomy is a safe and effective treatment for acute cholecystitis [154–158]. An early laparoscopic cholecystectomy is a safe treatment for acute cholecystitis and generally results in shorter recovery time and hospitalization compared to delayed laparoscopic cholecystectomies. (Recommendation 1A). Timing is perhaps the most important factor in the surgical treatment of acute gallstone cholecystitis (AGC). Evidence from published literature [159–162] Protein tyrosine phosphatase demonstrates that, compared to delayed laparoscopic cholecystectomies, early laparoscopic cholecystectomies performed to treat acute cholecystitis reduce both recurrence rates and the overall length of hospital stay. A promptly performed laparoscopic cholecystectomy is therefore the most cost-effective means of treating acute cholecystitis. In recent years, the medical community has debated the possible risk factors predictive of perioperative conversion to an open cholecystectomy from a laparoscopic approach in cases of acute cholecystitis [163, 164].