Such efforts could lead to a more robust understanding of the human health impacts of accelerating environmental change and inform decision making in the land-use planning, environmental conservation, and
public health policy realms.”
“The purpose of our study was to examine the altered gene expression associated with nongenotoxic chemical-mediated liver hypertrophy and successive liver tumor promotion. Five-week-old male rats were fed a basal diet or a diet containing phenobarbital (PB) or clofibrate (CF) for 3 days, 4 weeks, and 13 weeks. Hepatic expression profiling of cell growth- and stress-related genes, as well as those involved in xenobiotic metabolism, was performed by DNA microarray and/or real time quantitative reverse transcription-polymerase chain reaction. The induction of liver hypertrophy and hepatic cytochrome P450 (CYP) isoforms (CYP2B1/2B2 for PB and CYP4A1 for CF) by PB and CF Panobinostat mouse were clearly observed at all the treatment periods examined. Genes encoding DNA damage-inducible 45 (GADD45) family proteins, in particular GADD45g (GADD45 gamma) were down-regulated by treatment with either Rigosertib nmr PB or CF for 4 and 13
weeks. The chemical-mediated development of liver hypertrophy, induction of hepatic CYPs, and suppression of hepatic GADD45g gene at week 13 disappeared at 4 weeks following cessation of the chemical treatment. Additionally, DNA microarray data indicated that cell cycle-related genes such as cyclins CCNB1 and CCNA2 and Selleck SN-38 cyclin-dependent kinase inhibitor CDKN3 were also down-regulated by treatment with either PB or CF at 13 weeks. Since GADD45 functions as a chemical and radiation stress sensor by interacting with cyclins and cyclin-dependent kinase inhibitors, the decrease in the gene expression of GADD45g mRNA observed in this study, may be associated with nongenotoxic chemical-induced tumor promotion of hepatocarcinogenesis
rather than liver hypertrophy.”
“Objective: To determine diet and nutrition practices and the economic and social situation in homes with premature infants.\n\nMaterial and methods: A descriptive cross-sectional study of 100 preterm infants 30 to 36 weeks gestational age, using data obtained on weight, length and head circumference at birth, and whether they were from rural or urban communities. The mothers of premature infants were given a questionnaire to find out the diet and nutrition status, and the economic and social situation in the families. The preterm infants were recruited from Maternal and Child Hospital of Leon, Guanajuato.\n\nResults: The mean gestational age was 34 weeks (26 to 36). The mean weight, length, and head circumference at birth were: 2,007g (659 to 3,750g), 43.7 cm (30 to 52 cm) and 32.4 cm (28 to 35.5 cm), respectively. Almost all mothers (98%) wished to breastfeed.