When you look at the Russian Federation the death of elderly populace decreased up to 3,798.3 per 100 000 populace when you look at the 2018, for example. on 14per cent reduced in comparison with 2012 (4424.6), and on 45% reduced in comparison with matching indices in 1998 (6877.0 per 100 000 population). The objective of the analysis is always to identify qualities of mortality and also to compare with international information of death of population more than able-bodied age in the Russian Federation. The standard indices of mortality in 2012-2018 had been examined. The gender characteristics of mortality amounts had been founded. The main factors plus the structure of main factors behind death had been presented. The contrast of mortality prices. The share of specific age groups into complete death of populace regarding the Russian Federation through the years was described.The function of the study is always to evaluate dynamic of major and general morbidity of population more than able-bodied age in Moscow Oblast, including data comparing in the Central Federal Okrug and the Russian Federation. The info of analytical reports of City of Moscow, the Central Federal Okrug plus the Russian Federation in 2013-2018 had been a part of analysis. The typical analytical and mathematical statistical practices had been applied. It absolutely was founded that in Moscow Oblast in 2013-2018, up against the history of stagnation of main morbidity of population older than able-bodied age, indices of mental and behavioral problems, neoplasms and diseases of circulatory system. In addition, the level of primary morbidity for the area’s populace more than able-bodied age exceeds this 1 for the Russian Federation or perhaps the Central Federal Okrug in most classes of conditions. The structure of main morbidity have not changed and breathing diseases, injures and poisoning and conditions of circulatory system continue steadily to position very first locations. The degree of basic morbidity also stayed unchanged. But, morbidity of neoplasms, diseases of urinary tract and emotional and behavior disorders will continue to boost. The structure of basic morbidity of populace of this age-group differs the dwelling of major morbidity and conditions of circulatory, respiratory and musculoskeletal methods rated first places. Tracking and analysis of primary and basic morbidity of population avove the age of able-bodied age is important for building steps of its decreasing based on development of health social and geriatric treatment in the regions.The article provides the results for the evaluation of indices of morbidity of children and adults when you look at the Kostroma Oblast in 2000-2017. The main styles and changes during analyzed duration are set up. The large morbidity such courses of conditions as breathing diseases, injuries and poisoning, complications of being pregnant, childbirth and postpartum period are determined. The morbidity population within the Kostroma Oblast in the main courses of conditions increased by 14.3per cent in 2000-2017. The children morbidity in generation 0-14 many years continues to be high.The COVID-19 epidemic cause is recognized as is “patient zero” contaminated by coronavirus infection in December 2019 in China. However, accumulated facts dispute this version of occasions. Initial infected patient appeared in September in the us, in December – in France. in November-December pneumonia of comparable seriousness raged in Russia. It is hard to explain many outbreaks of simultaneous contagions in isolated staffs, including army immune exhaustion garrisons. In most of healthy adults’ antibodies to coronavirus are found. The most of infected patients do not have signs and symptoms of disease. To spell out these paradoxes ecological hypothesis is recommended – mankind and coronaviruses were interacting evolutionarily for thousands years in system of biogeocenosis, periodically confronting under influence of cyclical ecological processes. The purpose of research is to investigate commitment between mortality of intense out-of-hospital pneumonia, coronavirus people included, and cyclical variations of environmental ceen coronaviruses and human population.Sumoylation is among the crucial regulatory mechanisms in eukaryotes. Our earlier studies expose that sumoylation plays essential roles during lens differentiation (Yan et al. 2010. Proc Natl Acad Sci USA. 10721034-21039; Gong et al. 2014. Proc Natl Acad Sci American. 1115574-5579). Whether sumoylation is implicated in cataractogenesis, a disease mainly produced by aging, remains evasive. In our study, we’ve analyzed the altering patterns associated with the sumoylation ligases and de-sumoylation enzymes (SENPs) and their substrates including Pax6 and other proteins in cataractous contacts various age brackets from 50 to 90 yrs old. It is discovered that compared with normal contacts, sumoylation ligases 1 and 3, de-sumoylation enzymes SENP3/7/8, and p46 Pax6 tend to be demonstrably increased. In comparison, Ubc9 is significantly reduced. Among different cataract patients from 50s to 70s, male clients express more sumoylation enzymes and p46 Pax6. Ubc9 and SENP6 show age-dependent enhance.