No relationship between TNF-α polymorphism and SBI susceptibility was found in this study. Alzheimer’s disease (AD) is one of the most common types of chronic neurodegenerative diseases. Vascular dementia, AD and stroke are all associated with inflammation, but they have different initiating factors. Polymorphism in the TNF and apolipo protein E (APOE) was reported to increase AD risk. Laws Simon et al. [128] conducted a case–control

study and investigated −850C>T, rs1800629 in TNF and the APOE polymorphism in controls and patients with sporadic AD. The frequency of (−850C/T) genotypes and T allele was significantly different in AD individuals, while the (rs1800629) SNP was not associated with AD. Venetoclax nmr T allele of (−850) polymorphism significantly modified risk associated with possession of the APOE e4 allele only,

and (−850) T allele was found to be associated with lower levels of CSF Aβ42. In a Southern China population, patients with sporadic Alzheimer’s disease (SAD) have a significantly increased frequency of rs1800629 A-allele as compared with controls. The carriers of A-allele have a significantly increased risk of SAD. Level of TNF-α in serum of SAD group was much higher than that in control group, and the elevated serum MLN0128 chemical structure TNF-alpha level was closely associated with the risk of SAD detected by Yang et al. [129]. Seventeen studies that investigated the association between five TNF-α polymorphism (−850, rs1800629, rs1800630, rs361525 and rs1799964) and AD were retrieved and analysed [130]. The presence of T allele significantly increased the risk of AD associated with carriage of the apolipoprotein E epsilon 4 allele in Caucasian Australians and Northern Europeans. A significant association of (−850) polymorphism with AD risk and non-significant difference in genotype distribution of (rs1800629)

polymorphism in AD was found. Farnesyltransferase For the (rs361525 and rs1799964) polymorphism, Di Bona et al. [130] did not find an association with AD. Only four studies investigated rs361525 variant, and the results were not significant. Current findings suggested an association between (−850C>T) polymorphism and the risk of developing AD. No positive associations between TNF-alpha promoter haplotypes and AD disease in Italian population have been reported by Tedde et al. [131]. Tumour necrosis factor plays an important role in glutamatergic neural transmission [132] and serve essential functions in neural plasticity [133] and cognitive processes like learning and memory [134, 135]. SNPs in TNF have profound impact on this disease. A-allele of rs1800629 fastens cognitive processing speed in a visual task, compared with G-allele carriers [136]. Mental rotation describes the cognitive process of imagining an object turning around. Mental rotation is usually examined using objects (e.g. letters) that are rotated by certain degrees clockwise or counter-clockwise from the vertical upright.