Methods: We

analyzed www.selleckchem.com/products/crenolanib-cp-868596.html the urinary soluble Klotho levels in a cohort of 161 patients with stage 1–5 CKD and assessed the relationships between the urinary Klotho-to-creatinine ratio (Klotho/Cr), proteinuria and the kidney function. The patients were prospectively followed for two years to monitor for doubling of the baseline serum creatinine concentration and the initiation of renal replacement therapy. Results: Median urinary Klotho/Cr level was 0.35 μg/gCr (0.03–1.64) at baseline. The urinary Klotho/Cr level was positively correlated with eGFR and proteinuria and negatively correlated with changes in proteinuria during the follow-up period. The 117 patients followed for two years were categorized into two groups according to the baseline median urinary Klotho value. The 23 patients had progressed to renal end point. Renal survival was significantly lower in the patients with a urinary Klotho/Cr

ratio of ≤0.321 μg/gCr than in those with a urinary Klotho/Cr ratio of >0.321 μg/gCr (p = 0.0398). A Cox regression analysis adjusted INCB024360 order for age, gender, hypertension, diabetes, dyslipidemia, eGFR, proteinuria, hemoglobin, phosphate, fibroblast growth factor 23 and renin-angiotensin system blockade showed that a urinary Klotho/Cr ratio of >0.321 was significantly associated with a reduced risk for the renal end point. The adjusted odds ratio for a urinary Klotho/Cr ratio of >0.321 was 0.59 (95% confidential interval: 0.35–0.96; p = 0.0334). Conclusion: In this study, lower levels of urinary Klotho were significantly associated with renal outcomes, suggesting that a lower urinary Klotho level can serve as a novel biomarker for CKD progression. SAXENA ANITA, GUPTA Verteporfin AMIT, SHARMA RAJKUMAR Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow Introduction: Bioelectric impedance analysis (BIA) a simple noninvasive, bedside method for estimation of water

compartments which can be used in clinical settings. Study was undertaken to evaluate applicability of BIA as a screening tool for presence of kidney disease in general population by estimating body water compartments, creatinine clearance and glomerular filtration rate (GFR). Material and Methods: A cross-sectional non-hospital based study on randomly selected 52 subjects from general population. Maltron BIOSCAN analyzer 915/916 was used for evaluating water cpmpartments, creatinine clearance and GFR. Biochemical tests included hemoglobin, blood sugar random, liver function test (Bilirubin, SGPT, SGOT and Alkaline phosphatase), renal function test (serum creatinine and BUN), uric acid and urine microscopy. Blood pressure was checked.Total body water (TBW) derived using BIA was validated against Hume etal’s equations for estimating TBW. Results: Out of 52 subjects 24 (46.