[email protected] nl) (C) 2009 World Federation for Ultrasound in M

[email protected]) (C) 2009 World Federation for Ultrasound in Medicine

& Biology.”
“Peliosis hepatis is a rare histopathological entity of unknown etiology. We present a case of peliosis hepatis in a 44-year-old man with disseminated tuberculosis and acquired immunodeficiency syndrome. The diagnosis of peliosis hepatis was based on liver biopsy results which were suggestive of tuberculous etiology. Diagnosis of tuberculosis was confirmed by auramine stain, rRNA amplification and GNS-1480 inhibitor culture of Mycobacterium tuberculosis from synovial fluid of the elbow joint. The patient responded favourably to tuberculostatic treatment with four drugs and the early initiation of highly active antiretroviral therapy. Histopathological evidence of peliosis hepatis, without an obvious

cause, makes it necessary to rule out tuberculosis, especially in the context of immunodeficiency diseases and immigrants from endemic areas.”
“Objective: The outcome of aortic valve replacement for patients with low gradient severe aortic stenosis and preserved ejection fraction has been debated. The aim of the present study was to evaluate the effect of aortic valve intervention on survival in that group. Methods: A cohort of 416 consecutive patients with low gradient severe aortic stenosis (aortic valve area, smaller than = 1 cm(2); mean pressure gradient, smaller than 40 mm Hg) and preserved ejection fraction ( bigger than = 50%) were identified from the Sheba Medical Center echocardiography database. Clinical data, aortic valve intervention, and death GSK2126458 in vivo were recorded. Results: During an average follow-up of 28 months, of 416 study patients (mean age, 76 +/- 14 years, 42% men), 97 (23%) underwent aortic valve intervention and 140 (32%) died. Mantel-Byar analysis showed that the cumulative probability of survival was significantly greater after aortic valve intervention. Multivariate analysis revealed a 49% reduction in the risk of death after surgery (P smaller than .05). The survival benefit of aortic valve intervention

was comparable with adjustment to older age, aortic valve area smaller than = 0.8 cm(2), and a low ( smaller than = 35cm(2)/m(2)) or normal ( bigger than 35 cm(2)/m(2)) stroke volume index. Conclusions: Our findings suggest that aortic valve intervention is associated with improved survival among patients with low gradient severe aortic stenosis and preserved left Small Molecule Compound Library ventricular function. The presence of either a low or normal stroke volume index did not affect the mortality benefit.”
“Single-electron transmetalation has emerged as an enabling paradigm for the cross-coupling of C-sp(3) hybridized organotrifluoroborates. Cross-coupling of alpha-alkoxymethyl-trifluoroborates with aryl and heteroaryl bromides has been demonstrated by employing dual catalysis with a combination of an iridium photoredox catalyst and a Ni cross-coupling catalyst. The resulting method enables the alkoxymethylation of diverse (hetero)arenes under mild, room-temperature conditions.

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