Identification of the cell(s) of origin and the signaling pathway

Identification of the cell(s) of origin and the signaling pathways involved are challenging issues in liver cancers with pivotal implications in the clinicopathological and therapeutic perspectives. VINCENZO CARDINALE, M.D.1 “
“A 17-year-old girl presented with a history of elevated alkaline phosphatase and gamma-glutamyl transpeptidase AZD8055 clinical trial (γGT) levels for several years. She was asymptomatic and did not have jaundice, pruritus, abdominal pain, nausea, vomiting, weight loss, rashes,

or diarrhea. Viral hepatitis serologies, autoimmune serologies, and thyroid studies were all normal. γGT, gamma-glutamyl transpeptidase; MRCP, magnetic resonance cholangiopancreatography. She had a past medical history of anxiety, which was treated with Celexa. Otherwise, she was healthy and had no major childhood illnesses or history of substance abuse. She had traveled extensively with her family during her childhood, notably to Northern and Eastern Africa and Southeast Asia. Her physical examination was unremarkable. An abdominal

ultrasound examination was performed, and the findings were normal. Magnetic resonance cholangiopancreatography (MRCP) showed mild beading of the intrahepatic ducts Maraviroc concentration consistent with the diagnosis of primary sclerosing cholangitis involving the small ducts. The patient was started on ursodiol (300 mg three times per day), and her alkaline phosphatase and γGT levels promptly normalized. Subsequently, colonoscopy was performed to

rule out concomitant inflammatory bowel disease. The mucosa appeared normal on endoscopic examination, but random biopsy samples were taken to rule out quiescent colitis. The pathology specimens revealed schistosoma eggs, and stool studies were positive for Schistosomamansoni. Percutaneous liver biopsy was then performed to evaluate hepatic involvement. There were portal intravenular find more granulomas in two triads with a schistosoma egg with otherwise minimal lobular fibrosis There was no evidence of mucopolysaccharide production or hyperplasia of the ductular epithelium (Fig. 1). An endoscopic examination was negative for esophageal varices. She was treated with praziquantel, and ursodiol was continued. One year later, repeat MRCP showed minimal changes with resolution of duct dilation in segment 6. Schistosomiasis, which is also known as bilharzia, affects more than 207 million people worldwide, with 1 of every 30 people infected with the trematode. Free cercariae penetrate the skin, travel to the pulmonary vessels, and then eventually lodge in the liver; there, they mature, mate, and migrate distally against the venous flow in the portal system. Eggs pass through the intestinal wall into the bowel lumen. Chronic disease results from the ongoing host response to accumulating tissue-trapped eggs.

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