(C) 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.”
“Introduction:
Since ancient times, plant-based herbal formulations have been used in Indian traditional medicine to treat diabetes. This observational study investigated the antihyperglycemic, antihyperlipidemic, and antioxidant potential of a Gymnema sylvestre polyherbal formulation (“GSPF kwath”) in patients with type 2 diabetes mellitus. Methods: A before-and-after study of 32 human subjects with type 2 diabetes mellitus was carried out. Patients were administered “GSPF kwath” consisting of a mixture of 10 herbs: G. sylvestre (gurmar), Syzygium cumini (jamun seed), Phyllanthus emblica (amla), Curcuma longa (haldi), Pterocarpus marsupium (vijaysaar), Terminalia chebula (harad), Cassia fistula (amaltas), Picrorhiza kurroa (kutki), Swertia chirata (chirayita), and Terminalia bellirica (behada). Selleck Ruboxistaurin Patients P005091 inhibitor were administered 50 ml of aqueous extract derived from 10 g of “GSPF kwath” daily on an empty stomach for 6 months. The blood glucose levels were monitored monthly, and glycosylated hemoglobin,
lipid profile and biomarkers of oxidative stress, and liver and kidney function markers were measured at 3-monthly intervals. Results: Daily administration of “GSPF kwath” regularly for 6 months resulted in significant reductions of blood glucose and glycosylated hemoglobin levels. There was also a significant increase in high-density lipoprotein cholesterol levels and concomitant decreases in total cholesterol, LY294002 clinical trial triglyceride, low-density
lipoprotein cholesterol, and very-low-density lipoprotein levels. Patients exhibited a significant improvement in the biochemical markers for oxidative stress. Conclusions: The results suggest that the polyherbal formulation GSPF may have the potential to regulate both hyperglycemia and possibly hyperlipidemia. “GSPF kwath” may be a potentially safe and effective therapy for the treatment of type 2 diabetes mellitus. (C) 2015 Elsevier GmbH. All rights reserved.”
“Sequencing DNA in a synthetic solid-state nanopore is potentially a low-cost and high-throughput method. Essential to the nanopore-based DNA sequencing method is the ability to control the motion of a single-stranded DNA (ssDNA) molecule at single-base resolution. Experimental studies showed that the average translocation speed of DNA driven by a biasing electric field can be affected by ionic concentration, solvent viscosity, or temperature. Even though it is possible to slow down the average translocation speed, instantaneous motion of DNA is too diffusive to allow each DNA base to stay in front of a sensor site for its measurement. Using extensive all-atom molecular dynamics simulations, we study the diffusion constant, friction coefficient, electrophoretic mobility, and effective charge of ssDNA in a solid-state nanopore.