8,10 The difference between our findings and those of previous reports might be due to the differences in the animal model as well as the duration of diabetes and/or hypertension. There are various models of experimental hypertension and type 2 diabetes. Each model of such diseases portrays a specific aspect of such diseases in humans, and none of them is a full representation of the diseases. It would be interesting to examine how the simultaneity of other models of hypertension and type 2 diabetes would affect cardiac functions. Whether Inhibitors,research,lifescience,medical or not the findings of the present study can be extended to a combination

of other models and the significance of such findings needs further investigations. Conclusion The findings of the present study indicated that type 2 diabetes impaired cardiac functions, short-term renovascular hypertension improved cardiac functions, and simultaneity

of hypertension with type 2 diabetes attenuated the diabetes-induced cardiac impairment. Acknowledgment This work was supported Inhibitors,research,lifescience,medical Inhibitors,research,lifescience,medical by the Vice Chancellor for Research Affairs, Shiraz University of Medical Sciences. This paper is an extract from Azadeh Khalili’s PhD thesis. The authors declare no conflict of interest, financial or otherwise, with regards to this paper. Conflict of Interest: None declared.
Background: Medicinal plants are considered new resources for producing agents that could act as alternatives to antibiotics in the treatment of antibiotic-resistant bacteria. The aim of this study was to evaluate the antibacterial activity of 28 plant extracts

and oils against four Gram-negative bacterial species. Methods: Experimental, in vitro, evaluation of the activities of 28 plant Inhibitors,research,lifescience,medical extracts and oils Inhibitors,research,lifescience,medical as well as some antibiotics against E. coli O157:H7, Yersinia enterocolitica O9, Proteus spp., and Klebsiella pneumoniae was performed. The activity against 15 isolates of each bacterium was determined by disc diffusion method at a concentration of 5%. Microdilution susceptibility assay was used in order to determine the minimal inhibitory concentrations (MICs) of the plant extracts, oils, and antibiotics. MEK inhibitor review Results: Among the evaluated herbs, only Origanum syriacum L., Thymus syriacus Boiss., Syzygium aromaticum L., Juniperus foetidissima Wild, until Allium sativum L., Myristica fragrans Houtt, and Cinnamomum zeylanicum L. essential oils and Laurus nobilis L. plant extract showed anti-bacterial activity. The MIC50 values of these products against the Gram-negative organisms varied from 1.5 (Proteus spp. and K. pneumoniae( and 6.25 µl/ml (Yersinia enterocolitica O9 ) to 12.5 µl/ml (E. coli O:157). Conclusion: Among the studied essential oils, O. syriacum L., T. syriacus Boiss., C. zeylanicum L., and S. aromaticum L. essential oils were the most effective.