Injection of Anti bomologous Tissue Antisera.
Favour, Goldthwait, and Bayles reported the injection of cell free saline extracts of guinea pig synovia into rabbits. They subsequently PDK 1 Signaling injected into guinea pigs the rabbit anti guinea pig synovia serum obtained in this way, right after labelling with 1311. No antibody localization in the joints was detected nor was there histological proof of synovial lesions. Nearby Injection followed by Systemic Injection of Antigenic Materials. Faber described the injection of rabbit knee joints with killed streptococci, 14 to 65 days later on a further, intravenous injection was produced. Gross lesions produced only when additional intravenous injections have been given. Kinsella and Hagebush, making use of a freeze dried preparation of streptococci in the same method, developed an allergic arthritis. Moritz and Morley injected bacterial filtrates from B.
coli and B. typhosus into rabbit knee joints, and cutaneous injections have been given synchronously, PARP 20 to 30 hrs later intravenous injections of the same antigen were produced. 6 of eleven animals showed a synovial response, with endovascular damage, thrombosis, and vascular necrosis. Similar research have been created by Brunschwig and Henry. Angevine, Cecil, and Rothbard considered that a prior intra articular injection of killed streptococci or streptococcal nucleoprotein sensitized joints to a subsequent intravenous injection of homologous organisms, resulting in a far more chronic reaction than occurred when the preliminary injection was intravenous or intradermal. Morgan and Bennett made a persistent rabbit arthritis by frequently injecting extracts of the somatic antigen of the typhoid bacillus.
As with the classical Schwartzman response, there was in depth regional vascular injury with thrombosis and necrosis followed by fix. Other Observations on Sensitization to Foreign Substance. Jones, Carter, and Rankin emphasized that the capability of a series of injections of the polysaccharides extracted from Friedlanders Survivin bacillus to lead to joint adjustments was a measure neither of the anaphylactogenic nature of the extract, nor of its nitrogen or protein content. In the guinea pig there was no correlation amongst the occurrence of cardiac or of joint lesions, the alterations made by mucopolysaccharides from various sources have been non particular. Influence of Immunity on Infective Arthritis.
In a series of experiments with Streptobacillus moniliformis, Freundt showed that, even though death occurred also quickly in non immune groups for arthritis to produce, the joint irritation appeared in a relatively higher proportion Topoisomerase of surviving immunized animals. Disturbed immunological mechanisms in rheumatoid arthritis are proposed by numerous of the frequent characteristics of the illness. The place of gamma globulin and rheumatoid factor on synovial margins, for instance, has been confirmed. Nevertheless, there is no direct proof that rheumatoid arthritis is induced by a disorder of the immune mechanism, and it remains very likely that the serological criteria diagnostic of the ailment are linked and not causal features. In view of these points, it is doubtful regardless of whether any of the forms of experimental arthritis created by the stimulation of immunological mechanisms bear any accurate connection to the spontaneous condition.
Like the types of arthritis induced by chemical and physical agencies, they retain some value in the testing of analgesic medicines, but it can not be accepted that they have as yet thrown light on the pathogenesis of rheumatoid arthritis.