43 Its correlation with the HVPG has not been studied to date. Several investigations have demonstrated that the degree of portal hypertension is correlated with the severity of cirrhosis assessed by the Child-Pugh classification or the presence of ascites.2, 44 For example, low serum albumin levels and elevated prothrombin times are associated with the presence of severe portal hypertension but have not been correlated with the degree of portal hypertension.45 In one study, patients with low serum albumin levels, which were associated with low platelet counts and

large portal vein diameters, were more likely to have severe portal hypertension and varices.46 However, liver tests are not accurate enough to evaluate the presence and severity of portal hypertension and thus cannot be used to assess portal hypertension. The clinical diagnosis of severe portal hypertension by a physical examination is MLN8237 research buy not difficult in patients with cirrhosis who have collateral circulation of the abdominal wall, ascites, and peripheral edema. Hepatic encephalopathy Kinase Inhibitor Library is rarely the first sign of portal hypertension. Splenomegaly is frequent but is not always present in patients with portal hypertension. The relationship between the portal pressure and the spleen size remains unclear.47 The main result of splenomegaly is hypersplenism, which corresponds to a reduction

in some blood elements and most frequently a low platelet count with normal bone marrow function. The presence of hepatopulmonary syndrome or portopulmonary syndrome may reveal severe portal hypertension.48 Finally, an episode of gastrointestinal

hemorrhaging may also reveal portal hypertension and cirrhosis. There are two types of noninvasive methods that evaluate the clinical consequences of portal hypertension: techniques that evaluate the presence of varices and those that evaluate modifications in the splanchnic circulation and vessels (including hepatic veins). In patients with cirrhosis, the presence of esophageal varices indicates severe portal hypertension. In the absence of varices, moderate or severe portal hypertension may be present.13 No correlation exists between the degree of portal hypertension and the presence and PTK6 size of varices above a certain HVPG level (10-12 mm Hg).13, 14 Several methods exist for detecting esophageal varices, the degree of portal hypertension, and the presence and size of varices.7 At present, upper gastrointestinal endoscopy is the gold standard for determining the presence of varices.49, 50 This technique is uncomfortable and invasive for patients and is costly and time-consuming, Moreover, up to 50% of patients may not have developed varices 10 years after the diagnosis of cirrhosis. This proportion is likely to increase with the widespread use of noninvasive methods for detecting cirrhosis, which results in the detection of larger numbers of patients with compensated cirrhosis.