Importantly, yoga did not adversely affect or improve immune or virological status in these well-controlled HIV-infected adults. Yoga appears to be a low-cost, simple to administer, safe, nonpharmacological, popular and moderately effective behavioural intervention for reducing blood pressures in HIV-infected
people. The reduction in blood pressures observed with the practice of yoga in these pre-hypertensive Selleckchem LDE225 HIV-infected men and women is clinically relevant when considered in the context of anti-hypertension studies conducted in HIV-seronegative populations. Using tightly controlled dietary modification, the Dietary Approaches to Stop Hypertension (DASH) study reduced sodium intake in hypertensive participants who habitually consumed low, intermediate or high sodium levels, and reduced systolic blood pressure by 3.0, 6.2 and 6.8 mmHg , reductions of a similar magnitude to that observed in the current yoga study. In the PREMIER study, the DASH intervention was combined with established behavioural modifications
(weight loss by increased physical activity and reduced energy intake) in HIV-negative normo- and hypertensive African American and Caucasian men and women (mean age 50 years), and after only 6 months, systolic blood pressure was reduced by 2.1–5.7 mmHg , similar reductions to those observed for yoga. It is unlikely NVP-BKM120 that changes in dietary salt affected our findings because baseline
sodium intake in the HIV-infected participants was greater than AHA recommendations (1.5 g NaCl/day ), but it was not different between groups and was not reduced after either intervention. Our findings support the notion Edoxaban that, among traditional lifestyle modifications, the practice of yoga can be used to lower and manage systolic and diastolic blood pressures in pre-hypertensive HIV-infected people. The magnitude of the reduction in blood pressure observed here is similar to that observed in HIV-negative people with CVD risk factors who followed a yoga lifestyle intervention. Yoga tended to reduce blood pressure in studies of HIV-negative participants with the ‘metabolic syndrome’ , with and without previous coronary artery disease , and with hypertension . Perhaps the practice of yoga improves vascular function/tone, and this mediates the lowering of blood pressure . Conversely, in HIV-negative people with CVD risk factors, the practice of yoga appears to reduce body weight and glucose, insulin, triglyceride and proatherogenic lipoprotein levels [8–11]; beneficial effects that were not observed in the current study of people living with HIV.