The withdrawal time and experience level of the endoscopist were more important than the procedure order in detecting adenomas by colonoscopy. Key Word(s): 1. Time; 2. colon polyp; 3. adenoma; 4. procedure order Presenting Author: FUMIAKI KAWARA Additional Authors: TETSUYA YOSHIZAKI, YOSHIKO OHARA, SHINWA TANAKA, TSUKASA
ISHIDA, YOSHINORI MORITA, TAKASHI TOYONAGA, EIJI UMEGAKI, HIROSHI YOKOZAKI, TAKESHI AZUMA Corresponding Author: FUMIAKI KAWARA Affiliations: Kobe University Hospital, Kobe University Hospital, Kobe University Hospital, Kobe University Hospital, Kobe University Hospital, Kobe University PF-02341066 molecular weight Hospital, Kobe University Hospital, Kobe University Hospital, Kobe University Hospital Objective: Introduction: There remains many
unknown check details points about the diagnosis and the prognosis of duodenal polyps. In particular, little is known about the polyps which show gastric mucin phenotype by immunohistochemical staining. We report here the endoscopic and pathological findings of two duodenal polyp cases with gastric mucin phenotype. Methods: Case report: The patients were male in both cases, and the endoscopic examination revealed semipedunculated polyps over 20 mm in diameter in their duodenal bulb. Both polyps were soft and lobulated with reddish appearance, and some lobules had white deposition on them. In the Edoxaban case 1, microvascular dilation was observed at the top of the polyp by magnified narrow band imaging (NBI) system. On the other hand, the vasculature was uniform and regular without dilatation in case 2. Endoscopic mucosal resection (EMR) was performed for both cases. Pathological findings: The polyp in the case 1 was diagnosed as well differentiated tubular adenocarcinoma. It was hyperplastic polyp in the case 2. Evaluation by immunohistochemistry revealed that MUC5AC and MUC6 but not CD10 and MUC2 were expressed in both polyps, which confirmed the gastric mucin phenotype of these lesions.
Results: Discussion: Duodenal polyps with gastric mucin phenotype were thought to develop from the ectopic gastric mucosa, gastric metaplasia or Brunner’s gland. However, there are few reports about the characteristics of them, so the details are still unclear. Conclusion: We experienced both malignant and benign cases, which showed distinctive findings with NBI system. It would be important to accumulate the data of endoscopic features for the diagnosis of malignant or benign lobulated villous polyps with gastric mucin phenotype to analyze the correlation with pathological findings, which may also lead to the better understanding of the biological characteristics of these polyps. Key Word(s): 1. Duodenal polyp; 2. gastric mucin phenotype; 3.