Symptoms were assessed with Eckardt scores. The thickness of muscularis propria was measured endosonographically at 25 cm, 30 cm, 35 cm, and 40 cm from the incisors and at the gastroesophageal junction (GEJ). Of the 43 patients evaluated, 23 had spindle-type achalasia (Group A), 14 had flask-type (Group B), and 6 patients had sigmoid type (Group C). Results: The thickness of muscularis propria was significantly greater in Group C than A and

B when measured at 25 cm (P = 0.02) and 30 cm (P = 0.03) from the incisors. The thickness was greater in Group B than Group A and C when measured at 35 cm from the incisors (P = 0.01). There was no significant difference in the thickness of muscularis propria measured at the GEJ (P > 0.05) and 40 cm from the incisors

(P = 0.45) Angiogenesis inhibitor among the groups. There was very little correlation between the thickness and symptom scores (r = -0.2, P = 0.15), or the average pressure of the lower oesophageal sphincter (r = 0.3, P = 0.13). However, the duration of symptoms was negatively correlated with the thickness of muscularis propria (r = -0.5, P = 0.04). Conclusion: The appearance of muscularis propria thickening was common in patients with achalasia. EUS may be valuable in evaluating the severity of achalasia as we indicated an inverse relationship between the duration of symptoms and the thickness of the muscularis propria. Key Word(s): 1. POEM; 2. achalasia; Presenting Author: WEIXIANG MENG LDE225 clinical trial Additional Authors: GUOBAI XU, YAN LIU, LUOLUO YANG Corresponding Author: WEIXIANG MENG Affiliations: Jinlin University First Hospital; Jinlin University First Hospital Objective: Objective: To explore the sites, pathological type of the primary duodenal malignant tumors, especially differences in young and middle-aged and elderly patients and to find out inspection methods

in early. Methods: Methods: The statistics of 161 cases of diseased parts, the first symptoms, and the detection rate of the relevant Amisulpride checks, pathological features, and abnormal serum tumor markers of primary duodenal malignant tumors. To explore their respective characteristics and the value of early diagnosis of the disease. Results: Results: Young group and older group, with no specific clinical manifestations. The average duration from onset to diagnosis is 2.3 months. The tumors in young group patients mainly occur in the duodenal papilla. The tumors in elder group patients mainly occur in descending part (excluding nipple). There has no significant difference in the incidence of site between Two groups. The manly pathological type of the young group patients and older group patients are both adenocarcinoma. There has no significant difference in the in the pathological type between Two groups. The highest detectable rate of Auxiliary examination is duodenoscope, followed by ERCP. The highest detectable rate methods of serological detection are γ-GT and CA199. Conclusion: 1.