In addition, to date,

no study has specifically investigated the potential interaction between BMI and BFP as related to FL risk. By focusing our attention on the fact that FL occurs among both under and over-weight Japanese, we investigated the factors related to FL by using existing anthropometric data from health checkups, including height, weight, and body fat percentage, which are easily measurable at checkups. Then, we discussed the possibility of interaction between BMI and BFP in FL. We performed a cross-sectional study using data obtained from health checkups at Nishinarachuo Hospital Health Care Center, Nara Prefecture (Japan). Subjects included 3139 persons (1871 male, 1268 female) aged 30 years and over, who visited the Alisertib nmr center from January 2008 to March 2011, and who underwent a medical checkup, including abdominal ultrasonography. For those who underwent multiple checkups during the

study period, we used the first data for the analysis. In the biochemical workup, subjects who were found to be positive for hepatitis C virus antibody or HBs antigen were excluded. Of the 3139 patients, usable data were obtained MAPK inhibitor from

3110 patients (1851 male, 1259 female). This study was approved by the Ethics Committee of Nara (Japan) and Nishinarachuo Hospital, Mannose-binding protein-associated serine protease and conforms to the Declaration of Helsinki (as revised in Tokyo in 2004). Data obtained during the health checkup included anthropometrical measurements, biochemical tests, and ultrasonography findings. Height and weight were measured while wearing lightweight clothing and no shoes. BMI (kg/m2) was computed by dividing body weight (kg) by the square of the height (m). BFP was measured by a device using the body impedance method, with subjects holding a grip with both hands. BFP (%) was calculated as: mass of fat (kg)/body weight (kg) × 100. Systolic and diastolic blood pressures were measured in the seated position by an automatic blood pressure recorder at the center, using the subject’s right or left arm. Using a self-administered questionnaire, subjects provided information about their disease history and various lifestyle habits, including drinking habits, smoking status, regular exercise, and weight gain ≥10 kg since the age of 20.