Forty 3 patients had been ineligible Twelve of these patients

Forty three sufferers have been ineligible. Twelve of these sufferers were excluded based mostly selelck kinase inhibitor on clinical evidence for raised intracra nial stress, 12 had bilateral tumors not amenable to resection, 11 dem onstrated multifocal lesions on imaging, 6 had previously undergone biopsy of the minimal grade glioma, five did not meet a minimal KPS score of 50, three had a prior systemic malignancy, three had infratentorial lesions, 4 had lesions not amenable to greater than 75% resection, and 1 patient was medically unfit for craniotomy. Thirty sufferers have been excluded based on 1 exclusion criterion alone, 11 based mostly on two criteria, and 2 based mostly on 3 within the exclusion criteria. 3 in the eligible individuals would are already excluded soon after their surgical process primarily based on a last pathologic diagnosis inconsistent with malignant glioma. 6 extra patients inside the examine time period had nonenhancing mass lesions constant with very low grade glioma but final pathologic diagnosis con firmed malignant glioma.
Based on this series of sufferers, around 39 individuals annually meet eligibility criteria for randomization and 5% of these will be excluded submit method to get a diagnosis aside from malignant glioma. We predict that total enrollment for a trial evaluating biopsy versus resection of malignant glioma will need to be 344. Assuming 50% enrollment of potentially selleck eligible trial candidates, we predict yearly enrollment of 19 or 20 individuals at our institu tion. A multicenter trial with 10 comparable institutions could attain accrual in lower than two years. We system to proceed that has a pilot trial at 2 institutions. TA 27. PHASE II Examine OF ANTIANGIOGENIC CHEMOTHERAPY FOR RECURRENT MALIGNANT GLIOMAS S. Kesari,1 D. Schiff,two L. Doherty,one D. C. Gigas,1 T. T. Batchelor,3 A. Muzikansky,three A. ONeill,3 J. Drappatz,one A. Chen Plotkin,1 N.
Ramakrishna,one S. Weiss,1 B.

Levy,1 J. Bradshaw,one P. M. Black,1 J. Folkman,4 M. Kieran,1,4 and P. Y. Wen1, 1Dana Farber/Brigham and Womens Cancer Center, Boston, MA, USA, 2University of Virginia, Charlottesville, VA, USA, 3Massachusetts General Hospital, MA, USA, four Childrens Hospital, Boston, MA, USA Preclinical proof suggests that continuous very low dose daily chemotherapy may inhibit tumor endothelial cell proliferation and prevent tumor growth. We conducted a phase II review of continuous very low dose etoposide, alternating with cyclophospha mide, in combination with thalidomide and celecoxib in adult individuals with recurrent malignant gliomas. Individuals received VP 16 alternating with CP. Thalidomide was started at 200 mg daily and increased by 100 mg weekly. Celecoxib was started at 200 mg twice daily. MRI scans had been performed every 6 weeks. Individuals had been treated until tumor pro gression or unacceptable toxicity.

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