87 patients discontinued LdT and were followed up over 1 year. The HBV DNA negative rate was 86.3% (201/233) after 24 weeks of LdT treatment. The HBeAg loss rates at year 1, 2 and 3 were 55.9%, 60.0% and 63.8%, respectively, Small molecule library cell line for the HBeAg seroconversion, the rates were 45.9%, 52.6% and 57.1%, respectively. The sustained HBeAg seroconversion rate was 73.6% (64/87) in patients who were followed at least 1 year after drug withdrawal. The recurrence rate of patients experiencing HBsAg<1000 IU/ml was significantly lower than that in patients experiencing HBsAg>1000
IU/ml (13.5% (5/37) vs. 32.0% (16/50)), with significant difference (χ2=3.97, P<0.05). Decline in HBV DNA, HBeAg and HBsAg was factor predicting HBeAg seroconversion. Conclusion: LDT as a monotherapy
or as a combination therapy with ADV shows good antiviral efficacy. Consolidation therapy for more than 2 years after achieving HBeAg seroconversion, total > 3 years of treatment, as well as decline in HBV DNA, HBeAg and HBsAg are associated with durability HBeAg sero-conversion. [Key words] chronic hepatitis B, HBeAg-positive, HBeAg seroconversion, telbivudine Disclosures: The following people have nothing to disclose: Yang Ding, Chong Acalabrutinib clinical trial Zhang, Qiuju Sheng, Mingxiang Zhang, Feng Wu, Baojun Song, Weili Zhu, Jingyan Wang, Lilan Shi, Xiaoguang Dou Background & Aims Entecavir (ETV) and tenofovir (TDF) have been established as the two most potent initial agents for chronic hepatitis B (CHB) patients. Since there is a lack of objective data on whether the two drugs are similar in antiviral efficacy,or one is superior to the other, we
compared therapeutic outcomes between ETV- and TDF-treated CHB patients without prior therapy, specifically in the early phase. Methods This retrospective study included CHB patients with and without cirrhosis who were initially treated with 300mg/day TDF (n=99) or 0.5mg/day ETV (n=1,226). All patients had baseline HBV DNA levels >2,000 IU/mL and Child-Pugh class A liver function. We compared virological, serological, and biochemical responses between the TDF and ETV groups at week 48. Results Although proportion of cirrhosis (54.5% vs 41.6%) and mean serum alanine aminotransferase (ALT) level (119.4 vs 193.5 Clomifene IU/L) at baseline differed between the TDF and ETV groups (Ps<0.05), there was no significant difference in mean serum HBV DNA level (6.8 log10 vs. 6.9 log10 IU/ml) and percentage of HBeAg positivity (57.6% vs 55.4%; Ps=NS). At week 48, ALT normalization rate for all patients and HBeAg loss/seroconversion rate for HBeAg-positive patients were similar between the two groups (82.6% and 83.4%, and 19.3% and 16.8 % respectively; Ps=NS). The mean reductions in HBV DNA level at week 48 were -6.7 and – 6.5 log10 IU/mL, respectively, for the HBeAg-positive patients in the TDF and ETV groups (P=NS); and – 6.2 and – 6.0 log10 IU/mL, respectively for the HBeAg-negative patients (P=NS).