6. The pure drug tinidazole Fig. 6(a)
gives rise to a sharp peak that corresponds to melting point at 126 °C, indicates its crystalline nature. The pure polymer Eudragit L 100 and Eudragit S 100 exhibits a peak at 223 °C and 222 °C respectively, referring to the relaxation that follows the glass transition in Fig. 6 (b) and (c). The peak of drug did not appear in the thermogram of prepared microspheres, Dorsomorphin molecular weight it may indicate the drug was uniformly dispersed at the molecular level in the microspheres in Fig. 6 (d). From the result of present study, it can be concluded that Eudragit based tinidazole microspheres offer a high degree of protection from premature drug release in simulated upper GIT conditions and deliver most of the drug load in the colon and allow drug release to occur at the desired site by emulsion solvent evaporation system. A factorial method was used
in the study. Based on the results of the physicochemical characterization and in vitro drug release studies, it possessed all the required physicochemical characters and with drug releases up to 8 h where it released 92% of the tinidazole. Thus, Eudragit based tinidazole microspheres are a potential system for colon delivery of tinidazole for chemotherapy of amoebic infection. All authors have none to declare. Authors are thankful to MET’s Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nasik for providing necessary facilities to carry out this work. Authors are sincerely thankful to Sophisticated Test and Etomidate Instrumentation Center (STIC, Cochin, India) for providing facilities for SEM in AZD6244 mouse sampling. “
“Diabetes mellitus (DM) is a chronic disease caused by inherited or acquired deficiency in insulin secretion and by decreased responsiveness of the organs to secreted insulin.1 Diabetes mellitus is a syndrome, initially characterized by a loss of glucose homeostasis resulting from
defects in insulin secretion, insulin action both resulting impaired metabolism of glucose and other energy yielding fuels such as lipids and proteins.2 DM is a leading cause of end stage kidney disease, cardiomyopathy and heart attacks, strokes, retinal degeneration leading to blindness and non-traumatic amputations.3 Dyslipidemia, quite common in diabetic patients, is the main risk factor for cardiovascular and cerebrovascular diseases. DM is currently one of the most costly and burdensome chronic diseases and is a condition that is increasing in epidemic proportions throughout the world. Diabetes is a serious illness with multiple complications and premature mortality, accounting for at least 10% of total health care expenditure in many countries.4 The prevalence of diabetes of all age groups worldwide is projected to rise from 171 million in 2000 to 366 million in 2030.5 Reason of this rise includes increase in sedentary life style, consumption of energy rich diet, obesity, higher life span, etc.