5),99) Repeated imaging can avoid inappropriate use of aggressive medications or implantable devices. CMR is a good noninvasive modality that can give information about LV systolic function, valvular and pericardial pathologies and tissue characterizations. CMR can give important clues to identify the presence of reversible cardiomyopathy. Additional evidence is needed to understand how the detection of improvement at repeat imaging should be used to monitor the responsiveness to therapy and the implications this has for the duration of therapy. Acknowledgements Inhibitors,research,lifescience,medical Special thanks to inhibitor Crenolanib Cathryn Brock for her assistance in writing the table 1 manuscript.
A 52-year-old man with sudden onset of dyspnea was transferred to

our hospital. Transthoracic Inhibitors,research,lifescience,medical echocardiography showed an intimal flap ranged from sinus of Valsalva to sinotubular junction, with heterogenous hypoechoic materials within the flap (Fig. 1), and it caused

severe aortic regurgitation. Computed tomography scan showed linear dissection flap and aneurysmal dilatation in the sinus of Valsalva. Transesophageal echocardiography (TEE) demonstrated a suspicious dissection flap in the left coronary cusp with destroyed aortic valve (Fig. Inhibitors,research,lifescience,medical 2), with no color Doppler signal within this flap (Fig. 3). We estimated the diagnosis as Type A aortic dissection requiring emergency operation. From the operative findings, however, the patient was diagnosed to have infective endocarditis involved the left coronary cusp of aortic valve and sinus of Valsalva which caused dissection. Therefore, we performed aortic valve replacement and sinus of Valsalva repair. The operation finished successfully. Inhibitors,research,lifescience,medical The pathologic findings of hypoechoic materials within the flap showed Inhibitors,research,lifescience,medical chronic inflammation with neutrophil infiltration. Even though the pathogen was not proved in the several times of blood culture, we treated the patient with 6 weeks of antibiotics and

anticoagulation therapy. Fig. 1 Transthoracic echocardiography. The parasternal long axis view demonstrates an intimal flap (arrow) ranged from sinus of Valsalva to sinotubular junction, with heterogenous hypoechoic material within the flap (between arrowheads). Fig. 2 Transesophageal echocardiography. Mid esophageal aortic valve short axis view demonstrates a dissection flap (arrow) with destroyed left coronary cusp of aortic valve (arrowheads). Fig. 3 Transesophageal echocardiography. Mid esophageal aortic valve short axis view Anacetrapib demonstrates no color Doppler signal within the flap (arrows). A sinus of Valsalva aneurysm is a rare disorder. Although usually congenital, it may be associated with endocarditis, trauma, or aortic dissection.1),2) Once ruptured, sinus of Valsalva aneurysm may produce serious hemodynamic instability, such as acute heart failure or sudden death.3) When a sinus of Valsalva aneurysm is suspected, immediate diagnosis should be pursued with TEE.