Conclusions.— The Pediatric Migraine Disability Assessment provides a simple tool to measure the impact of selleck inhibitor headaches in adolescents. Adolescents with migraine headaches suffered the greatest level of disability. Higher depression scores were associated with more severe headache-related disabilities in adolescents, independent of headache frequency and severity. “
“Migraine is a chronic, episodic, often disabling, neurological condition that affects more than 12% of the US population, 3 times more in women than men. It has widespread effects on cerebral function and appears to be inherited. There are many types of therapy including
behavioral, complementary, acute pharmacologic care, preventive pharmacologic care, and physical techniques. General treatment principles include
lifestyle changes and using rapidly acting Nutlin-3 order acute care medications alone or in combination early in the migraine attack. Migraine-specific medications such as triptans and non steroidal anti-inflammatory drugs should be used when possible. There are several promising medications and devices in the migraine pipeline. “
“Background.— One of the genome-wide linkage studies performed in migraine has yielded a significant linkage of migraine (with and without aura) with markers located at 6p12.2-21.1. This locus (named MIGR3) has not been replicated in the only genome-wide association Org 27569 scan
study performed to date or in previous genome-wide linkage studies. Objective.— Our objective had been to replicate the MIGR3 locus performing a family-based association study. Methods.— A sample of 594 subjects belonging to 134 migraine families of diverse complexity underwent genotyping for the markers previously published as linked at 6p12.2-21.1 migraine locus. Family-based association test, under different models of inheritance, and also the model-free TDT analysis were performed. Results.— The best result was obtained with the D6S1650 marker under the additive model (rank [S observed] = 265.0; permuted P = .0006), using family-based association test program (HBAT subprogram). Similar results were obtained with the model-free TDTPHASE algorithm (P < .0001, corrected). Nominal significant P values were obtained for D6S1630, D6S452, and D6S257. After correction for multiple testing with the stratified false-discovery rate, all markers showed significant association (P < .0001). Conclusion.— We corroborated that the MIGR3 locus at 6p12 is a genetic risk for migraine with and without aura. (Headache 2012;52:393-399) "
“This article describes a single case of migraine headaches misdiagnosed as idiopathic intracranial hypertension in a young woman. The implications of such a diagnosis are discussed. Literature regarding normal intracranial pressure is reviewed.